Ovulation induction and normal pregnancy after panhypopituitarism due to lymphocytic hypophysitis.

BACKGROUND Lymphocytic hypophysitis is an unusual autoimmune disease that causes partial or total hypopituitarism and often is associated with pregnancy. Only four spontaneous pregnancies have been reported after this disease. We report a case of ovulation induction in a woman with this antecedent as well as the course of the subsequent pregnancy. CASE Ovulation was induced with gonadotropins in a 31-year-old woman with panhypopituitarism secondary to lymphocytic hypophysitis, achieving an uncomplicated single intrauterine pregnancy. A term healthy infant was delivered by cesarean. Clinical course during puerperium was normal. CONCLUSION Ovulation induction response was similar to that in panhypopituitarism of any other cause. Lymphocytic hypophysitis antecedent did not adversely affect pregnancy outcome nor was pregnancy-related disease relapse observed.